液-液相分离技术引领核酸递送革命：ProteanFect® 斩获多项国际顶级期刊权威验证
【中国，2026年8月】Nanoportal Biotech（西湖凝聚体）旗下核心产品 —— 基于内源蛋白凝聚体（液-液相分离，LLPS）原理开发的 ProteanFect® 系列核酸递送试剂，在国际顶尖学术殿堂持续大放异彩。多项由国内外顶尖科研团队主导的重磅研究相继在 Nature Cell Biology、Nature Biotechnology、Nature Communications、Signal Transduction and Targeted Therapy、Nature Microbiology、Cell Reports 以及 Science Advances 等国际顶级学术期刊上发表。
这标志着 ProteanFect® 卓越的递送效能、超高细胞活率与极简温和的操作体验已获得全球生命科学与免疫学界的高度认可与权威验证。
全细胞系、全荷载类型通用：
产品线全面覆盖 PT01 至 PT09 多款型号，完美兼容 siRNA、mRNA、质粒及 Cas9 RNP 等多种核酸荷载，广泛应用于肿瘤免疫、细胞治疗、基因编辑、抗病毒天然免疫与免疫代谢调控研究。
ProteanFect® PT系列部分引用文献
No. | Journal | Cell Type | Cargo type | Product SKU | PubMed ID |
1 | Nature Biotechnology | Jurkat cells | plasmid | PT01 | 41652223 |
2 | Science Advances | Jurkat cells | plasmid | PT01 | 41417896 |
3 | Journal of Advanced Research | Jurkat cells | plasmid | PT01 | 41248710 |
4 | Nature Communications | Jurkat cells | plasmid | PT01 | 42251048 |
5 | Advanced Science | Jurkat cells | plasmid | PT01 | 41926643 |
6 | Nature Genetics | THP-1 cells | siRNA | PT01 | 41286103 |
7 | Nature Communications | THP-1 cells | siRNA | PT01 | 42168171 |
8 | Cell Reports | Primary human T cells | siRNA and mRNA | PT02 | 41950005 |
9 | The Journal for ImmunoTherapy of Cancer | Primary human CD8+ T cells | plasmid | PT02 | 41802813 |
10 | Bioactive Materials | Cord blood NK cells | siRNA | PT02 | 41674556 |
11 | Cancer Immunology, Immunotherapy | Mouse ascitic CD19+ B cells | siRNA | PT02 | 41984099 |
12 | Nature Cell Biology | Primary mouse CD8+ T cells | siRNA | PT03 | 40925954 |
13 | Phytomedicine | Primary mouse CD8+ T cells | siRNA | PT03 | 41418634 |
14 | Oncogenesis | Primary mouse CD8+ T cells | siRNA | PT03 | 41651808 |
15 | Nature Microbiology | Primary mouse CD4+ Treg cells | siRNA | PT03 | 41073667 |
16 | Phytomedicine | Primary mouse CD8+ T cells | siRNA | PT03 | 42275879 |
17 | Biochemical and Biophysical Research Communications | Primary mouse T cells | mRNA | PT03 | 42119177 |
18 | Cell Reports | Primary mouse T cells | siRNA and mRNA | PT03 | 41950005 |
19 | Redox Biology | Primary mouse CD8+ T cells | siRNA | PT03 | 42520384 |
20 | Cell Discovery | K562 cells | Cas9 mRNA and sgRNA | PT04 | 42575881 |
21 | Nature Communications | Primary human CD8+ T cells | Cas9 mRNA and sgRNA | PT05 | 40817373 |
22 | Signal Transduction and Targeted Therapy | Primary mouse CD4+ T cells | Cas9 mRNA and sgRNA | PT06 | 40854873 |
23 | European Journal of Immunology | Primary mouse CD4+ T cells | Cas9 mRNA and sgRNA | PT06 | 41830088 |