Technology
What is EASY?
EASY is a mammalian coacErvAte-baSed drug deliverY technology platform, designed for the efficient and targeted delivery of nucleic acids, proteins, small molecules, and other therapeutic agents into cells. EASY is engineered from mammalian proteins capable of forming coacervates, which allow for the encapsulation, protection, and intracellular delivery of therapeutic molecules. Unlike traditional delivery methods, EASY employs a non-viral, non-electroporation, and non-liposomal approach, ensuring optimal biocompatibility, high delivery efficiency, and minimal cytotoxicity. By leveraging the unique properties of endogenous coacervate-forming proteins, EASY enables precise intracellular delivery across a wide range of cell types, including primary immune cells, without needs for harsh physical or chemical treatments. Beyond its applications in ex vivo cell engineering, EASY is also designed for in vivo delivery, offering a safe and effective method for systemic or localized therapeutics.
How EASY Works
Efficient Delivery Using Protein Coacervates
-
01
Self-assemblyEndogenous proteins
+ nucleic acids -
02
High-payload
coacervatesThousands of nucleic acid
molecules per particle -
03
Efficient cell entryNon-classical
endocytic pathways -
04
Cargo release &
carrier degradationUbiquitination-driven
degradation -
05
Efficient
expressionmRNA translation
/ gene editing
encoded by mRNA mRNA translation
ProteanFect™ Series - The First Product Developed From EASY Platform
Make The Primary Cell Transfection Simple
ProteanFect enables the successful delivery of mRNA into a wide range of primary cells, including T cells, NK cells, stem cells, neurons, cardiomyocytes, and more
High Nucleic Acid Payload Capacity
ProteanFect-formed particles encapsulate hundreds of thousands of nucleic acid molecules, significantly exceeding the payload capacity of lipid nanoparticles
Superior Cell Compatibility And Safety
ProteanFect achieves higher transfection efficiency and better cell viability in primary cells compared to electroporation, ensuring both safety and optimal performance
Easily Scalable For High-Throughput Applications
ProteanFect facilitates the successful transfection of multiple wells with various mRNA molecules, making it ideal for high-throughput applications in large-scale genetic studies