Liquid-Liquid Phase Separation Sparks a Revolution in Nucleic Acid Delivery: ProteanFect™ Featured Across Prestigious International Journals
[August 2026] — Powered by breakthrough endogenous protein coacervates (liquid-liquid phase separation, LLPS) technology, Nanoportal Biotech’s flagship ProteanFect® series has achieved widespread recognition, driving major research breakthroughs published in top-tier academic journals including Nature Biotechnology, Nature Communications, Cell Reports, and Science Advances.
This milestone underscores the exceptional transfection efficiency, superior cell viability, and mild, streamlined operation of ProteanFect®, which have been rigorously validated by the global life science and immunology research communities.
The expanded product portfolio fully supports universal nucleic acid cargos including siRNA, mRNA, plasmids, and Cas9 RNPs, empowering cutting-edge applications in tumor immunology, cellular immunotherapy, gene editing, antiviral innate immunity, and immunometabolic regulation.
Selected Peer-Reviewed Citations (ProteanFect® PT Series)
No. | Journal | Cell Type | Cargo type | PubMed ID |
1 | Nature Biotechnology | Jurkat cells | plasmid | 41652223 |
2 | Science Advances | Jurkat cells | plasmid | 41417896 |
3 | Journal of Advanced Research | Jurkat cells | plasmid | 41248710 |
4 | Nature Communications | Jurkat cells | plasmid | 42251048 |
5 | Advanced Science | Jurkat cells | plasmid | 41926643 |
6 | Nature Genetics | THP-1 cells | siRNA | 41286103 |
7 | Nature Communications | THP-1 cells | siRNA | 42168171 |
8 | Cell Reports | Primary human T cells | siRNA and mRNA | 41950005 |
9 | The Journal for ImmunoTherapy of Cancer | Primary human CD8+ T cells | plasmid | 41802813 |
10 | Bioactive Materials | Cord blood NK cells | siRNA | 41674556 |
11 | Cancer Immunology, Immunotherapy | Mouse ascitic CD19+ B cells | siRNA | 41984099 |
12 | Nature Cell Biology | Primary mouse CD8+ T cells | siRNA | 40925954 |
13 | Phytomedicine | Primary mouse CD8+ T cells | siRNA | 41418634 |
14 | Oncogenesis | Primary mouse CD8+ T cells | siRNA | 41651808 |
15 | Nature Microbiology | Primary mouse CD4+ Treg cells | siRNA | 41073667 |
16 | Phytomedicine | Primary mouse CD8+ T cells | siRNA | 42275879 |
17 | Biochemical and Biophysical Research Communications | Primary mouse T cells | mRNA | 42119177 |
18 | Cell Reports | Primary mouse T cells | siRNA and mRNA | 41950005 |
19 | Redox Biology | Primary mouse CD8+ T cells | siRNA | 42520384 |
20 | Cell Discovery | K562 cells | Cas9 mRNA and sgRNA | 42575881 |
21 | Nature Communications | Primary human CD8+ T cells | Cas9 mRNA and sgRNA | 40817373 |
22 | Signal Transduction and Targeted Therapy | Primary mouse CD4+ T cells | Cas9 mRNA and sgRNA | 40854873 |
23 | European Journal of Immunology | Primary mouse CD4+ T cells | Cas9 mRNA and sgRNA | 41830088 |